Toxic Effects of Cypermethrin in Female Rabbits

The aim of the present study was to explore the fetotoxic effects of cypermethrin (CY) in female rabbits with low and high doses. For this purpose, 32 adult female rabbits were divided in to four equal groups A, B, C and D. Rabbits of groups A, B and C were treated with different levels of CY at the dose rate of 25, 50 and 75 mg/kg body weight intraperitoneally, while the group D served as a control and was given equal volume of normal saline intraperitoneally. The clinical signs exhibited by the rabbits treated with CY included salivation, licking of different body parts, muscular tremors, ataxia and convulsions. There was a significant difference in the numbers of CL and number of fetuses which mean the early embryonic death and post implantation loses at the high dose. There were microscopic changes in the ovaries and uteri of animals treated with CY.